Yield of Post-acute Diverticulitis Colonoscopy for Ruling out Colorectal Cancer

BACKGROUND AND AIMS: Colonoscopy is recommended for post-acute diverticulitis (AD) to exclude underlying colorectal cancer (CRC). However, post-AD colonoscopy utility remains controversial. We aimed to examine yield of post-AD colonoscopy in our predominately Hispanic patient population. METHODS: Patients undergoing post-AD colonoscopy between November 1, 2015 and July 31, 2021 were identified from a prospectively maintained endoscopic database. AD cases without computed tomography confirmation were excluded. Pertinent data were abstracted, including whether patients had complicated or uncomplicated AD; fecal immunochemical test (FIT) result post-AD and precolono-scopy; number, type, and location of nonadvanced adenomas; advanced adenomas; and CRC. Analyses were conducted using 2-sample Wilcoxon rank sum and Fisher exact tests. RESULTS: Two hundred eight patients were included, of whom 62.0% had uncomplicated AD. Median age was 53 years, 113 (54.3%) were female, and 161 (77.4%) were Hispanic. Ninety nonadvanced adeno-mas were detected in 45 patients (21.6%), in addition to eight advanced adenomas in 8 patients (3.8%). Two patients (1.0%) had CRC, both of whom had complicated AD in the same location seen on imaging, and 1 of whom was FIT positive (the other had not undergone FIT). Patients with uncomplicated vs com-plicated AD had similarly low rates of advanced adenomas (4.7% vs 2.5%, P = 0.713). FIT data were avail-able for 51 patients and positive in 3 (5.9%); nonadvanced adenomas were found in all 3 patients who were FIT positive. No patient who was FIT negative had an advanced adenoma or CRC. CONCLUSION: Colonoscopy post-AD is generally low yield, with CRC rarely being found and only in those with complicated AD. Colonoscopy post-complicated AD appears advisable, whereas less invasive testing (eg, FIT) may be considered for post-uncomplicated AD to inform the need for colonoscopy.