One Pot Approach of Novel Xanthan Perchloric Acid Catalyst in Synthesis of Bis(Indolyl)Methane Derivatives Via Greener Perspective

A convenient, eco-friendly electrophilic reaction of indole with substituted aromatic aldehydes to yield bis(indolyl)methane (BIM) derivatives. BIM derivatives are synthesized in one pot by employing a biopolymer-derived novel heterogeneous catalyst, Xanthan Perchloric Acid (XPA). The Catalyst XPA is prepared from biopolymer xanthan and treated with perchloric acid. XPA is thermally stable with sufficient acidic sites, mild, nontoxic, and reusable. The reaction proceeds smoothly at room temperature in the green context, shorter reaction time, and excellent yield under solvent-free conditions.