Pegozafermin Improved Liver Histology, Liver-related Noninvasive Tests (NITs) and Metabolic Profiles in an Open-label Cohort of a Phase 1b/2a Study in Subjects with Non-alcoholic Steatohepatitis

Rohit Loomba,Naim Alkhouri,Shibao Feng,Leo Tseng,Germaine D. Agollah,Hank Mansbach,Maya Margalit,Cynthia L. Hartsfield,Stephen A. Harrison

JOURNAL OF HEPATOLOGY（2023）

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摘要

Purpose: Pegozafermin (PGZ), a long-acting glycoPEGylated recombinant human FGF21 analog, had significant liver-related and cardiometabolic benefits, with favorable safety and tolerability, in a Phase 1b/2a study in NASH.

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关键词

metabolic profiles,liver-related,non-invasive,open-label,non-alcoholic

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