The Mechanosensitive Ion Channel PIEZO1 in Intestinal Epithelial Cells Mediates Inflammation through the NOD-Like Receptor 3 Pathway in Crohn's Disease.

Qiuyuan Liu, Didi Wang,Xiaodong Yang,Fang Ma, Wei Han,Jing Hu,Qiao Mei

INFLAMMATORY BOWEL DISEASES（2023）

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摘要

PIEZO1 in intestinal epithelial cells caused calcium influx, which resulted in mitochondrial dysfunction and activated the NLRP3 inflammasome, mediating intestinal inflammation.

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关键词

Crohn’s disease,NLRP3 inflammasome,PIEZO1,intestinal inflammation,mechanosensitive ion channel

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