Synthesis, bioassay and molecular docking of novel pyrazole and pyrazolone derivatives as acetylcholinesterase inhibitors

-Synthesis of pyrazole and pyrazolone derivatives (1), (3) and (4).-In silico study of pyrazole and pyrazolone derivatives as (AChE) inhibitors.-In vitro (AChE) inhibition study of pyrazole and pyrazolone (1), (3) and (4).-pyrazolone derivative (1) exhibited good inhibitory activity against AchE.-pyrazolone derivative (1) has potential for in vivo anti-Alzheimer evaluations.