Integrated Multi-Cohort Analysis of the Parkinson's Disease Gut Metagenome.

Joseph C Boktor,Gil Sharon,Leo A Verhagen Metman,Deborah A Hall,Phillip A Engen,Zoe Zreloff,Daniel J Hakim,John W Bostick,James Ousey,Danielle Lange,Gregory Humphrey,Gail Ackermann,Martha Carlin,Rob Knight,Ali Keshavarzian,Sarkis K Mazmanian

Movement disorders : official journal of the Movement Disorder Society（2023）

引用 3|浏览34

暂无评分

摘要

A metagenomic meta-analysis of PD shows consistent and novel alterations in functional metabolic potential and microbial gene abundance across four independent studies from three continents. These data reveal that stereotypic changes in the functional potential of the gut microbiome are a consistent feature of PD, highlighting potential diagnostic and therapeutic avenues for future research. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

查看译文

关键词

Parkinson's disease,dysbiosis,gut microbiome,microbial metabolism,shotgun metagenomics

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要