Loss of intraflagellar transport 140 in osteoblasts cripples bone fracture healing

Qiqi Fan,Xuekui Wang, Mengqi Zhou,Yubei Chen,Dike Tao, Songxi Rong,Shuang Zhou,Hui Xue,Yao Sun

Fundamental Research（2022）

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摘要

•Fracture-susceptible bone like aged femurs exhibited a decrease in Ift140 expression.•Ift140 deletion in osteoblasts conferred compromised bone fracture rehabilitation, while its overexpression facilitated fracture recovery.•Ift140 in osteoblasts relayed inhibitory signal to BMSC for chondrogenesis and osteogenesis.

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关键词

Primary Cilia,Intraflagellar Transport 140,Bone fracture,Osteoblasts,Bone Mesenchymal Stem Cells

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