Poster: CML-363 Recent Perspective of Next-Generation Sequencing (NGS) in Non-BCR::ABL Mechanisms of Resistance in Patients with Chronic Myeloid Leukemia

Daria Kustova,Ekaterina Motyko,Anna Kirienko, Marina Bakay,Elizaveta Efremova, Natalya Semenova,Natella Enukashvily,Sergei Voloshin,Vasily Shuvaev, Sergei Sidorkevich,Irina Martynkevich

Clinical lymphoma myeloma & leukemia/Clinical lymphoma, myeloma and leukemia（2022）

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摘要

The detection of multiple mutations in patients with CML may explain resistance to TKI therapy; however, to better understand the pathogenesis of CML, it is important to know not only the presence of certain mutations but also their level of expression and to study the effects of various regulatory elements, such as transcription factors and miRNAs.

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CML,NGS,chronic myeloid leukemia,non-BCR::ABL mechanisms of resistance

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