A study of the interactions between human osteoblast-like cells and polymer composites with functionalized graphene derivatives using 2D correlation spectroscopy (2D-COS)

Anna Kołodziej,Aleksandra Wesełucha-Birczyńska,Elżbieta Długoń,Małgorzata Świętek,Maciej Gubernat,Łukasz Skalniak,Marta Błażewicz

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy（2023）

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摘要

•Nanocomposites composed of a PCL and GO/rGO graphene derivatives were studied.•Raman 2D-COS analysis can be used for early testing of bioactivity.•2D-COS revealed a complex cellular response in U-2 OS cells on the PCL/GO material.•PCL modification with GO improves the biocompatibility of the material.

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关键词

Polymer nanocomposite,Poly(ε-caprolactone) (PCL),Graphene oxide (GO),Reduced graphene oxide (rGO),Raman micro-spectroscopy,2D correlation spectroscopy (2D-COS)

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