Heavy-flavor impact on CTEQ-TEA global QCD analyses

We discuss heavy-flavor production at hadron colliders in recent global QCD analyses to determine parton distribution functions (PDFs) in the proton. We discuss heavy-flavor treatments in precision theory predictions at the LHC. In particular, we discuss factorization schemes in presence of heavy flavors in proton-proton collisions, as well as the impact of heavy-flavor production at the LHC on PDFs. We show results of recent updates beyond CT18, the latest global QCD analysis from the CTEQ-TEA group.