Distinct transcriptomic and metabolomic profiles characterize NSAID-induced urticaria/angioedema patients undergoing aspirin desensitization

Sen Hee Tay,Amelia Santosa,Eugene Chen Howe Goh, Chun Xiang Xu, Lik Hang Wu,Mei Bigliardi-Qi,Leroy Sivappiragasam S/O Pakkiri,Bernett Teck Kwong Lee,Chester Lee Drum,Paul Lorenz Bigliardi

Journal of Allergy and Clinical Immunology（2022）

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摘要

This is the first study to combine both transcriptomic and metabolomic approaches in patients with NIUA, which contributes to a deeper understanding about the pathogenesis of NIUA and may potentially pave the way toward a molecular diagnosis of NSAID hypersensitivity.

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关键词

Nonsteroidal anti-inflammatory drug,hypersensitivity,aspirin,desensitization

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