Genetic variation in NFE2L2 is associated with outcome following aneurysmal subarachnoid haemorrhage.

Ben Gaastra, Poppy Duncan,Mark K Bakker,Isabel C Hostettler,Varinder S Alg,Henry Houlden,Ynte M Ruigrok,Ian Galea,Will Tapper,David Werring,Diederik Bulters

European journal of neurology（2023）

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摘要

The NFE2L2 SNP, rs10183914, is significantly associated with outcome following aSAH. This is consistent with a clinically relevant pathophysiological role for oxidative and inflammatory brain injury due to blood and its breakdown products in aSAH. Furthermore, our findings support NRF2 as a potential therapeutic target following aSAH and other forms of intracranial haemorrhage.

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关键词

NF-E2-related factor 2,polymorphism, single nucleotide,subarachnoid haemorrhage

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