Functional mechanism of EGR3 in cerebral ischemia/reperfusion injury in rats by modulating transcription of pri-miR-146a/146b to miR-146 and suppressing SORT1 expression

Bin Han,Jing Wang,Fengyun Hu,Yi Liu,Yaxuan Sun,Kun Meng, Pengyu Lu, Haifeng Tang

Brain Research（2022）

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摘要

•EGR3 shows poor expression in CIRI and upregulated EGR3 mitigates CIRI in rats.•EGR3 overexpression attenuates oxidative stress and mitochondrial injury in vitro.•EGR3 facilitates miR-146 transcription.•Overexpression of miR-146 relieves oxidative stress and mitochondrial injury.•Upregulated SORT1 abrogates the protection of overexpressed miR-146 against OGD/R.

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关键词

Cerebral ischemia/reperfusion injury,EGR3,miR-146,SORT1,Oxidative stress,Mitochondrial injury,Oxygen-glucose deprivation,Neurons

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