Irisin inhibits NLRP3 inflammasome activation in HG/HF incubated cardiac microvascular endothelial cells with H/R injury.

Chao Xin,Jinglong Zhang, Ningbo Hao,Jianan Wang,Hui Liu,Hanwen Wei,Yong Wang, Chengzhu Wang, Shuo Wang,Chengrong Zheng,Zheng Zhang,Zhitao Jin

Microcirculation (New York, N.Y. : 1994)（2022）

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摘要

The current study demonstrated for the first time that irisin inhibits NLRP3 inflammasome activation in CMECs as a novel mechanism in myocardial ischemia/reperfusion injury in diabetes.

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关键词

CMECs,NLRP3 inflammasome,diabetes,irisin,myocardial ischemia/reperfusion

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