Removal of clinically significant antibiotics from aqueous solutions by applying unique high-throughput continuous-flow plasma pencil and plasma brush systems

•Plasma pencil and plasma brush were applied for continuous degradation of antibiotics.•Plasma brush was ≈10 times more effective than the plasma pencil.•Mainly OH, O, O3, H2O2, and HO2− are involved in degradation of antibiotics.•Degradation is caused by the O attack to aromatic ring, as found with UPLC-MS/MS.•Antimicrobial properties of plasma brush-treated drugs solution dropped up to 81%