Intraoperative use of extracorporeal CO 2 removal (ECCO 2 R) and emergency ECMO requirement in patients undergoing lung transplant: a case-matched cohort retrospective study

Background The use of extracorporeal carbon dioxide removal (ECCO 2 R) is less invasive than extracorporeal membrane oxygenation (ECMO), and intraoperative control of gas exchange could be feasible. The aim of this study in intermediate intraoperative severity patients undergoing LT was to assess the role of intraoperative ECCO 2 R on emergency ECMO requirement in patients. Methods Thirty-eight consecutive patients undergoing lung transplantation (LT) with “intermediate” intraoperative severity in the intervals 2007 to 2010 or 2011 to 2014 were analyzed as historical comparison of case-matched cohort retrospective study. The “intermediate” intraoperative severity was defined as the development of intraoperative severe respiratory acidosis with maintained oxygenation function (i.e., pH <7.25, PaCO 2 >60 mmHg, and PaO 2 /FiO 2 >150), not associated with hemodynamic instability. Of these 38 patients, twenty-three patients were treated in the 2007–2010 interval by receiving “standard intraoperative treatment,” while 15 patients were treated in the 2011–2014 interval by receiving “standard intraoperative treatment + ECCO 2 R.” Results ECMO requirement was more frequent among patients that received “standard intraoperative treatment” alone than in those treated with “standard intraoperative treatment + ECCO 2 R” (17/23 vs. 3/15; p = 0.004). The use of ECCO 2 R improved pH and PaCO 2 while mean pulmonary artery pressure (mPAP) decreased. Conclusion In intermediate intraoperative severity patients, the use of ECCO 2 R reduces the ECMO requirement.