Phase 1 Study of the Combination of Escalated Total Marrow Irradiation Using Helical Tomotherapy and Fixed High-Dose Melphalan (140 mg/m²) Followed by Autologous Stem Cell Transplantation at First Relapse in Multiple Myeloma.

Axel Cailleteau,Philippe Maingon,Sylvain Choquet,Rémi Bourdais,Delphine Antoni,Bruno Lioure,Cyrille Hulin,Stéphanie Batard,Camille Llagostera,Valentine Guimas,Cyrille Touzeau,Philippe Moreau,Marc-André Mahé,Stéphane Supiot

International Journal of Radiation Oncology*Biology*Physics（2023）

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摘要

Total marrow irradiation provides good results with a good tolerance profile at first relapse in MM and makes it possible to increase the dose delivered to the planning target volume while sparing organs at risk. This technique could be discussed for all regimens before auto- or allo-stem cell rescue when TBI is required.

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关键词

escalated total marrow irradiation,multiple myeloma,autologous stem cell transplantation,helical tomotherapy,high-dose

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