Acute baclofen administration promotes functional recovery after spinal cord injury

Nídia de Sousa,Andreia G Pinho,Susana Monteiro, Valentina Liberato,Diogo J Santos,Jonas Campos,Jorge R Cibrão,Nuno A Silva,Antón Barreiro-Iglesias,António J Salgado

The Spine Journal（2023）

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摘要

Our outcomes revealed that baclofen, a well-known drug used for spasticity management, improves the motor performance after SCI in a pre-clinical animal model. Our data opens new avenues for pharmacological strategies design to promote SCI recovery.

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关键词

Baclofen,Spinal Cord Injury,Functional recovery,GABAergic drugs,Immune response modulation,Neuroinflammation

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