Synthesis of Pyrrole Disulfides Via Umpolung of Β-Ketothioamides.
Organic & biomolecular chemistry(2022)
摘要
A Na2CO3-promoted reaction of β-ketothioamides (KTAs) and cyanoacetates was developed for the synthesis of pyrrole disulfides using air as a green oxidant. This protocol features a broad substrate scope and mild reaction conditions. Preliminary mechanistic studies indicate that the reaction involves a tandem unusual umpolung of KTAs, N-cyclization, tautomerization and oxidative coupling process.
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