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Mycotic infection as a risk factor for COVID-19: A meta-analysis

Frontiers in Public Health(2022)SCI 3区

Guangzhou Med Univ

Cited 3|Views22
Abstract
More than 405 million people have contracted coronavirus disease 2019 (COVID-19) worldwide, and mycotic infection may be related to COVID-19 development. There are a large number of reports showing that COVID-19 patients with mycotic infection have an increased risk of mortality. However, whether mycotic infection can be considered a risk factor for COVID-19 remains unknown. We searched the PubMed and Web of Science databases for studies published from inception to December 27, 2021. Pooled effect sizes were calculated according to a random-effects model or fixed-effect model, depending on heterogeneity. We also performed subgroup analyses to identify differences in mortality rates between continents and fungal species. A total of 20 articles were included in this study. Compared with the controls, patients with mycotic infection had an odds ratio (OR) of 2.69 [95% confidence interval (CI): 2.22-3.26] for mortality and an OR of 2.28 (95% CI: 1.65-3.16) for renal replacement therapy (RRT). We also conducted two subgroup analyses based on continent and fungal species, and we found that Europe and Asia had the highest ORs, while Candida was the most dangerous strain of fungi. We performed Egger's test and Begg's test to evaluate the publication bias of the included articles, and the p-value was 0.423, which indicated no significant bias. Mycotic infection can be regarded as a risk factor for COVID-19, and decision makers should be made aware of this risk.
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corona virus disease (COVID-19),mycotic infection,risk factor,meta-analysis,subgroup analysis
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要点】:本研究通过元分析发现真菌感染是COVID-19的一个风险因素,并可能导致更高的死亡率和肾替代疗法需求。

方法】:研究采用PubMed和Web of Science数据库搜索相关文献,利用随机效应模型或固定效应模型计算合并效应大小,并进行了亚组分析。

实验】:共纳入20篇文章,通过Egger's检验和Begg's检验评估纳入研究的发表偏倚,发现真菌感染患者的死亡风险和肾替代疗法需求的风险比对照组显著增加,其中欧洲和亚洲的真菌感染风险最高,念珠菌是最危险的真菌菌株。