MAPK activated kinase 2 inhibition shifts the chemokine signature in arthritis synovial fluid mononuclear cells from CXCR3 to CXCR2

Tue W. Kragstrup,Anne Sofie Sørensen,Mads Brüner,Søren Lomholt,Morten A Nielsen,Peter Schafer,Bent Deleuran

International Immunopharmacology（2022）

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摘要

•MK2 inhibition on the secretory profile of synovial fluid mononuclear cells.•C-X-C motif chemokine receptors 3 (CXCR3) chemokines were decreased.•CXCR2 chemokines were increased.•This shift may be one of the mechanisms behind the anti-inflammatory effects of MK2 inhibitors.

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关键词

Kinase,Small molecules,Psoriatic arthritis,Rheumatoid arthritis,Spondyloarthritis,Immune-mediated inflammatory arthritis

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