Histone Deacetylase 3 Governs β-Estradiol-ERα-Involved Endometrial Tumorigenesis via Inhibition of STING Transcription.

Guofang Chen,Qiang Yan, Lin Liu,Xinyue Wen,Hongliang Zeng,Shasha Yin

Cancers（2022）

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摘要

This study reveals a novel molecular mechanism by which HDAC3 inhibits STING transcription via β-estradiol-ERα and provides a promising therapy (a combination of HDAC and STING) for combating endometrial cancer.

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关键词

ERα,H3K4,HDAC3,RGFP966,STING,endometrial cancer,therapy

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