Fluorogenic gemcitabine based light up sensor for serum albumin detection in complex biological matrices
Colloids and Surfaces B: Biointerfaces(2022)
摘要
Herein we report fluorogenic derivative of gemcitabine (GEM-DNS), synthesized from gemcitabine hydrochloride and dansyl chloride in a single step. Owing to its large stoke shift of ∼200 nm and intriguing photophysical properties, the said dye has been utilized to estimate albumin concentration in complex bio-media such as human urine and blood serum. High sensitivity and selectivity towards albumin make the aforementioned dye a powerful diagnostic tool to detect ailments such as liver cirrhosis, diabetes, hypertension etc.
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关键词
Serum albumin,Gemcitabine,Dansyl chloride,Photoluminescence
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