Synthesis and Neuraminidase Inhibitory Activity of Sialic Acid Analogues with Fluoro, Phosphono, and Sulfo Functionalities.

Christopher J Vavricka,Nongluk Sriwilaijaroen,Yasuo Suzuki,Hiromasa Kiyota

Methods in molecular biology (Clifton, N.J.)（2022）

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摘要

Methods to synthesize influenza virus inhibitors with fluoro, phosphono, and/or sulfo functional groups are described. The resulting sialic acid analogues are produced from the natural substrate N-acetylneuraminic acid as starting material. Fluorescent assay methods for inhibition of influenza neuraminidase and virus proliferation are also provided.

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Fluoro-sialic acids,Influenza virus,Neuraminidase,Phosphono-sialic acids,Sulfo-sialic acids

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