Interactions between symptoms and psychological status in irritable bowel syndrome: An exploratory study of the impact of a probiotic combination.

David Groeger,Eileen F Murphy, Hern Tze Tina Tan, Ida Søgaard Larsen, Ian O'Neill,Eamonn M M Quigley

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society（2023）

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摘要

These findings suggest that the stress response is a major driver of IBS symptoms. The time course of the beneficial effect of COMBO on IBS symptoms suggests that this is achieved through a restoration of the stress response. In contrast, the time course of the effects of COMBO on anxiety and depression in IBS paralleled an anti-inflammatory effect as indicated by a reduction in circulating levels of TNF-α.

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anxiety,cortisol,depression,inflammation,irritable bowel syndrome,sleep,stress

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