A new high-throughput HBV integration sequencing approach shows that mitochondrial DNA is frequently targeted by virus integration in liver cells with active HBV replication

D. Giosa,D. Lombardo,C. Musolino,V. Chines,G. Raffa,F. Casuscelli di Tocco,D. D'Aliberti,C. Saitta,A. Alibrandi,R. Aiese Cigliano,O. Romeo,G. Navarra,G. Raimondo,T. Pollicino

Digestive and Liver Disease（2022）

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摘要

Background: Although research on HBV DNA integration has made relevant progress, important aspects remain unclear. Development of new integration detection methods may help in improving knowledge in the field and in HBV-related tumorigenesis.

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关键词

active hbv replication,mitochondrial dna,virus integration,high-throughput

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