Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1 H )-ones and their polyfluoroalkyl-containing analogs

S. O. Kushch, M. V. Goryaeva,Ya. V. Burgart,G. A. Triandafilova, K. O. Malysheva, O. P. Krasnykh, N. A. Gerasimova, N. P. Evstigneeva,V. I. Saloutin

Russian Chemical Bulletin（2022）

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摘要

The three-component cyclization of 3-polyfluoroalkyl-3-oxopropanoates and methyl ketones with ammonium acetate affords 6-organyl-4-(polyfluoroalkyl)pyridin-2(1 H )-ones (organyl is alkyl, aryl, or hetaryl). The synthesized pyridones were evaluated for antifungal, antibacterial, and analgesic activity.

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关键词

ethyl trifluoroacetoacetate, 3-polyfluoroalkyl-3-oxopropanoates, methyl ketones, ammonium acetate, three-component reaction, 4-(trifluoromethyl)pyridin-2-ones

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