A GMP Protocol for the Manufacture of Tregs for Clinical Application.

Alice O'Neil,Matthew Brook,Seetha Abdul-Wahab,Joanna Hester,Giovanna Lombardi,Fadi Issa

Methods in molecular biology (Clifton, N.J.)（2023）

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摘要

Infusion of regulatory T cells is a promising therapeutic strategy in organ transplantation to modulate the immune system, prevent rejection, minimize the need for pharmaceutical immunosuppression, and improve long-term transplant outcomes. Here we describe a GMP-compliant method we have used for the manufacture of ex vivo expanded autologous regulatory T cells for use in clinical trials.

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关键词

Immunosuppression minimization,Regulatory T cells,Tolerance,Transplantation,Treg

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