Neurohemodynamic correlates of BDNF gene expression in schizophrenia patients with working memory deficits: A functional MRI study

Sowmya Selvaraj,Venkataram Shivakumar, Paranthaman V Kavya,Thrinath Mullapudi,Gaurav Bhalerao,Vanteemar S Sreeraj,Satish Suhas,Damodharan Dinakaran,Rujuta Parlikar,Harleen Chhabra,Janardhanan C Narayanaswamy,Monojit Debnath,Naren P Rao,Kesavan Muralidharan,Ganesan Venkatasubramanian

Asian Journal of Psychiatry（2022）

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摘要

•Schizophrenia patients had maximum activation in left DLPFC in working memory task.•There was positive association between BDNF gene expression & left DLPFC activation.•There was negative association between BDNF gene expression & negative symptoms.•Also, a negative association between left DLPFC activation & negative symptoms.•Study elicited the role of BDNF gene expression in working memory in schizophrenia.

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关键词

BDNF,BMI,BOLD,CPZ,CDSS,DLPFC,DSST,fMRI,HMSE,LNST,MINI,PBMC,PCR,RMANOVA,SANRS,SANS,SAPS,SOFAS,WMD

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