Comments on: Huang S. et al. “Biofluid Biomarkers of Alzheimer's disease: Progress, problems, and perspectives.” Neuroscience Bulletin (2022)

This paper by Huang S., et al. has retrospectively described the recent progress in biomarkers based on the A-T-N-X framework, A-T-N respectively represents Amyloid-Tau-Neurodegeneration, X represents biomarkers from central or peripheral related to the whole pathological course of Alzheimer's disease (AD). The framework of A-T-N-X is of great significance for understanding the whole spectrum of AD, but we still want to stress the importance of urine biomarkers for the early identification and effective management of AD.