A novel telomerase-derived peptide GV1001-mediated inhibition of angiogenesis: Regulation of VEGF/VEGFR-2 signaling pathways

Jae Hyeon Kim,Young-Rak Cho,Eun-Kyung Ahn,Sunho Kim,Surim Han,Sung Joon Kim,Gyu-Un Bae,Joa Sub Oh,Dong-Wan Seo

Translational Oncology（2022）

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摘要

•GV1001, a human telomerase-derived peptide, inhibits endothelial cell proliferation, migration, invasion, tube formation and microvessel sprouting.•GV1001 regulates VEGF-A-stimulated signaling network components including FAK, Src, MEK, ERK and AKT pathways.•GV1001 suppresses VEGF-A-induced expression of VEGFR-2 and MMP-2.

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关键词

GV1001,Telomerase-derived peptide,Angiogenesis,VEGF,Non-small cell lung cancer

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