miR-642a-5p increases glucocorticoid sensitivity by suppressing the TLR4 signalling pathway in THP-1 cells

Juan Luo,Yijie Wang,Xiangqian Dong,Wen Wang,Yanju Mu,Yang Sun,Fengrui Zhang,Yinglei Miao

Biochemistry and Biophysics Reports（2022）

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摘要

The incidence rate of ulcerative colitis (UC) is increasing annually, and glucocorticoid (GC) resistance (GCR) is a common cause of UC-induced remission failure. Our previous studies have shown that the expression of miR-642a-5p is downregulated in UC with GCR, suggesting that miR-642a-5p may be related to the GC response. Therefore, we investigated the mechanism by which miR-642a-5p regulates the GC response in THP-1 cells.

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关键词

miR-642a-5p,Toll-like receptor 4,Glucocorticoid sensitivity,Glucocorticoid resistance,Ulcerative colitis

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