The Therapeutic Effects of Seven Lycopodium Compounds on Cell Models of Alzheimer's Disease.

Qian Guo, Qinfeng Cai,Fang Huang,Zhen Wei,Jian-Zhi Wang,Bin Zhang,Rong Liu,Yang Yang,Xiaochuan Wang,Hong-Lian Li

Journal of Alzheimer's disease : JAD（2022）

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摘要

Among the seven Lycopodium compounds, 2JY-OBZ4 showed the most expected effects on promoting cell viability, downregulating tau hyperphosphorylation, and Aβ production and inhibiting AChE in AD.

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关键词

Alzheimer’s disease,Lycopodium alkaloid,beta-Secretase 1,cholinesterase inhibitor,protein phosphatase-2A

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