Neonicotinoid insecticides promote breast cancer progression via G protein-coupled estrogen receptor: In vivo, in vitro and in silico studies

Xin Li,Sen He,Han Xiao,Ting-Ting He,Jia-Da Zhang,Zi-Rui Luo,Jie-Zhi Ma,Yu-Long Yin,Lin Luo,Lin-Ying Cao

Environment International（2022）

引用 5|浏览10

暂无评分

摘要

•Neonicotinoids bind to and activate G protein-coupled estrogen receptor (GPER).•Neonicotinoids induce breast cancer cells migration via GPER in vitro.•Acetamiprid up-regulate 4T1 cells GPER mRNA expression in a dose-dependent manner.•Acetamiprid promote breast cancer proliferation and migration via GPER in vivo.•GPER is a potential molecular target for the estrogenic disruption of neonicotinoids.

查看译文

关键词

Neonicotinoid insecticides,G protein-coupled receptor,Estrogenic disruption effect,Breast cancer,Signal pathway,Molecular initiation event

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要