BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice

Eliza Bollinger,Matthew Peloquin, Jenna Libera,Bina Albuquerque,Evanthia Pashos,Arun Shipstone,Angela Hadjipanayis,Zhongyuan Sun,Gang Xing,Michelle Clasquin,John C. Stansfield,Brendan Tierney, Steven Gernhardt, C. Parker Siddall, Timothy Greizer, Frank J. Geoly, Sarah R. Vargas, Lily C. Gao, George Williams, Mackenzie Marshall

Molecular Metabolism（2022）

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摘要

•Treatment of DIO mice with BDK inhibitor BT2 rapidly improved insulin sensitivity.•BT2 treatment improved liver pathology in multiple models of NALFD/NASH.•Feeding-induced hepatic gene changes were ameliorated in BT2-treated DIO mice.•BT2 treatment may improve metabolism by activating PPARα in a paracrine manner.•Liver-specific BDK knockdown with AAV did not improve metabolism nor activate PPARα.

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关键词

BCAA,Metabolism,Metabolic syndrome,NAFLD,Diabetes

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