Effects of tocotrienol on osteocyte-mediated phosphate metabolism in high-carbohydrate high-fat diet-induced osteoporotic rats

Sok Kuan Wong, Nur Irdina Adlin Fikri, Karthikgeyan Munesveran, Nur Syaqeerah Nor Hisham, Shirley Hui Jin Lau,Kok-Yong Chin,Nur Azlina Mohd Fahami,Qodriyah Hj Mohd Saad,Yusof Kamisah,Azman Abdullah,Norliana Masbah,Soelaiman Ima-Nirwana

Journal of Functional Foods（2022）

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摘要

•Osteocytes act as mechanosensory cells to control bone remodelling.•Lower osteocyte numbers and higher empty lacunae are detected in bone loss.•Lower DMP1 and PHEX levels are detected in bone loss.•Longer treatment period is required to observe the changes in phosphate level.

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关键词

DMP1,Metabolic syndrome,Osteoporosis,PHEX,Phosphates,Vitamin E

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