On the structure and stability of novel cationic DPPC liposomes doped with gemini surfactants

•A novel formulation of cationic liposomes was studied by mixing DPPC with cationic gemini surfactants.•The phase transition was interpreted in terms of Ising model parameters.•Gemini surfactants into the lipid bilayer of DPPC liposomes induce changes phase transition.•The location of the Gemini surfactant in the bilayer depends on the length of the spacer.•The colloidal stability of DPPC liposomes with gemini surfactants at a low molar ratio is dramatically increased.