Towards high entropy alloy with enhanced strength and ductility using domain knowledge constrained active learning

•A domain knowledge constrained active learning loop alloys was proposed.•The valence electron concentration criterion was used to narrow down the unexplored space and ensure the ductility.•One alloy with an ultimate strength of 1258 MPa and an elongation of 17.3 % was synthesized, which outperform the existed alloys.•The eutectic microstructure can increase the strain hardening ability and promote the uniform deformation by preventing crack propagation.