[Bone Marrow Osteoblasts Promotes the Proliferation Leukemia Stem Cell by Up-regulating Interleukin-1].

Zhi-Jie Cao, Yi-Shuang Li,Hui-Jun Wang,Zhen-Ya Xue,Shu-Ying Chen,Ke-Jing Tang,Min Wang,Qing Rao

Zhongguo shi yan xue ye xue za zhi（2022）

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摘要

Osteoblast niche can promote leukemia cell proliferation and self-renewal through up-regulating the expression of IL-1 in leukemia cells. In AML patients, the expression level of IL-1 was correlated to the percentage of CD34 positive cells in BMMNC.

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关键词

interleukin-1,leukemia stem cells,osteoblast niche

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