Recent advancements in nanoelectrospray ionization interface and coupled devices

•Nanoelectrospray ionization interface is designed to couple various sample treatment technologies with mass spectrometry.•New developments in spray emitters, sample injection methods and electrical contact are reviewed.•Newly-developed nanoelectrospray interface improved sensitivity, stability and robustness.•Future developments are believed to be focused on demands of trace biosample analysis, high throughput reactions screening and ultra-high sensitive analysis.