Ru-Catalyzed Enantioselective Hydrogenation of Diaryl 1,4-Diketones: Synthesis of Chiral 1,4-Diarylbutane-1,4-Diols

Asymmetric hydrogenation of diaryl 1,4-diketones was achieved by using trans-RuCl2[(S)-BINAP)][(S)-Daipen] as the catalyst and the reaction gave rise to excellent enantio-and diastereoselectivities (up to >99% ee and de). This procedure provides a convenient and efficient synthetic method for chiral 1,4diarylbutane-1,4-diols, which are important intermediates for a variety of chiral auxiliaries and ligands.