Functionalized poly(oligo(lactic acid) methacrylate)-block-poly(oligo(ethylene glycol) methacrylate) block copolymers: A synthetically tunable analogue to PLA-PEG for fabricating drug-loaded nanoparticles

Lukas P. Sadowski, Andrew Singh, Daniel H. Luo,Michael J. Majcher,Ivan Urosev,Meghan Rothenbroker, Vitaliy Kapishon,Niels M.B. Smeets,Todd Hoare

European Polymer Journal（2022）

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摘要

•Brush copolymer analogues of PEG-PLA copolymers were produced via ATRP or ARGET ATRP.•Functionalization of either block was achieved via copolymerization.•Resulting nanoparticles have tunable stability and appropriate size/polydispersity.•High drug loading is achievable with hydrophobic drug payloads (>96% encapsulation)

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关键词

Brush polymers,Amphiphilic copolymers,Self-assembly,Drug delivery,ATRP,Poly(oligo(ethylene glycol) methacrylate)

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