Numerical investigation of bio-inspired mixing enhancement for enzymatic hydrolysis

•A novel dynamic intestinal model takes account of an enzyme secretion boundary.•The Se number is proposed to identify and quantify the secondary flow.•After a segmentation cycle of 2 s, the maximum mixing level reaches 41.8%.•The mixing level is increased by 76.0% at the highest viscosity of 5 Pa·s.•Shear strain rate (<220.4 s−1) in the system is suitable for enzymatic hydrolysis.