Metabolomics implicate eicosanoids in severe functional mitral regurgitation

Thomas M. Hofbauer,Klaus Distelmaier,Besnik Muqaku,Georg Spinka,Veronika Seidl,Henrike T. Arfsten,Gerhard Hagn,Samuel Meier‐Menches,Philipp E. Bartko,Noemi Pavo, Matthias Hoke,Suriya Prausmueller,Gregor Heitzinger,Dietmar Pils,Irene M. Lang,Christian Hengstenberg,Martin P. Hülsmann,Christopher Gerner,Georg Goliasch

ESC Heart Failure（2022）

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摘要

We report the up-regulation of various eicosanoids in patients with severe FMR, with 8,9-DiHETrE appearing to predict mortality. Our observations may serve as a nucleus for further investigations into the causes and consequences of metabolic derangements in this important valvular abnormality.

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关键词

Eicosanoids,Functional mitral regurgitation,Heart failure,Metabolomics

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