The roles of rat medial prefrontal and orbitofrontal cortices in relapse to cocaine-seeking: A comparison across methods for identifying neurocircuits

•Prelimbic cortex inactivation consistently attenuates cocaine relapse.•The effect of infralimbic cortex inactivation on cocaine relapse depend on post-cocaine training.•Recent work finds that several subregions of orbitofrontal regulate cocaine relapse.•Optogenetics/DREADD methods yield the same effects as pharmacological inactivation.