Mannobioside Biomimetics That Trigger DC-SIGN Binding Selectivity

Irene Herrera-Gonzalez,Michel Thepaut,Elena M. Sanchez-Fernandez,Antonio di Maio,Corinne Vives,Javier Rojo,Jose M. Garcia Fernandez,Franck Fieschi,Pedro M. Nieto,Carmen Ortiz Mellet

Chemical communications（2022）

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摘要

Selective DC-SIGN targeting vs. langerin might lead to anti-infective agents, given their counteracting effects upon infection by some pathogens. Here we show that multivalent sp2-iminosugar-containing mannobioside analogs can achieve total DC-SIGN selectivity by levering the canonic binding mode towards high-mannose oligosaccharide ligands, behaving as factual biomimics.

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