Efficacy of a Polyherbal Supplement in Enhancing Immune Cells in Individuals Frequently Susceptible to Cold and Flu

Abstract Objectives Human immune system is a complex network of cells and proteins which protects the body from various infections. Therefore, optimal functioning of immune system is critical to fight against infections. OmniActive has developed a polyherbal supplement consisting of Ashwagandha, Boswellia, Neem, Ultrasol Curcumin, and Star Anise to modulate the human immune system and provide protection against infections. Objective of the study was to evaluate the efficacy of immune supplement (IS) in healthy human subjects frequently susceptible to cold and flu. Methods Thirty subjects completed this randomized, double-blind, parallel, placebo-controlled study. Subjects were randomized to either IS or placebo groups and instructed to consume one tablet every morning after breakfast for 60 days. Efficacy assessments included blood measures for WBC, WBC differential, Absolute Lymphocytes, Platelets, IgG, IgM, CD4 and CD8, CD4/CD8 ratio, CD45, CD3, Natural killer (CD (16 + 56), CRP, Perceived Stress Score (PSS), Pittsburgh Sleep Quality Index (PSQI), and Common Cold Questionnaire (CCQ) at baseline, day 30 and day 60. Safety was evaluated by monitoring adverse events. Statistical analysis was conducted using ANOVA to evaluate the mean change from baseline for IS in comparison to placebo. Results The IS group showed significant improvement (p < 0.05) as compared to placebo in the markers of innate immunity with an increase in WBC, natural killer cells, and platelet counts. Further IS group also showed significant improvements (p < 0.05) in the markers of adaptive immunity through an increase in the number of absolute lymphocytes, lymphocytes %, CD4 (Helper T Cells), CD8 (Suppressor T-Cells), CD4/CD8 ratio, CD3 (T Cells), CD45, IgG at several time points in the study. A significant decrease (p < 0.05) was also noted in CRP levels and common cold symptoms with the IS group. No adverse events related to the treatment were observed. Conclusions The clinical study findings suggest that there was a significant improvement in the overall immune status of subjects without any adverse events related to immune supplement. The immune supplement could be beneficial for individuals looking for herbal alternatives to enhance immune system and protection from infections. Funding Sources OmniActive Health Technologies Limited.