SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis.

Liping Wang,Dongliang Liang,Yinyin Huang,Yunxin Chen, Xiaocong Yang,Zhijun Huang,Yiqin Jiang,Hanfu Su,Lijing Wang,Janak L Pathak,Linhu Ge

Journal of advanced research（2022）

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摘要

SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of P. gingivalis. A higher abundance of P. gingivalis during SAP deficiency could promote M1 macrophage polarization and periodontitis. This finding suggests the possible protecting role of elevated levels of periodontal SAP against periodontitis progression.

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关键词

C5a-C5aR signaling,Macrophages,Periodontitis,Porphyromonas gingivalis,Serum amyloid P component

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