Abstract 5878: The prognostic model of colorectal liver metastases contribute extended molecular profiling

Abstract Background: Over half of colorectal cancer (CRC) patients will metastasize at the same/different times, Only 15-20% of patients are considered resectable at the time of diagnosis. The clinical situation attributed to the clinical heterogeneity of metastatic colorectal cancer(mCRC), the prognosis of patients with mCRC at different metastatic sites is different. The proportion of higher is colorectal liver metastasis (CRLM) and the mechanism of CRLM is complicated,studies have found cancer-related genes expand the predictive molecular profile of survival, The aim of this analysis was to verify and further develop the genetic risk scores. Methods: In this study, bioinformatics methods were used to comprehensively analyze the CRLM cohort (n=270) in the database. The cohort patients were divided into high-risk group and low-risk group. Independent data (n=105) verified the prognostic validity of the model. Results: The models established by commonly genes(APC, BRAF, ERBB2, KRAS, NRAS, PIK3CA, TP53, SMAD2-4) of CRLM were confirmed by prognostic markers. Differences between high-risk prognostic groups compared to low-risk were significant (HR = 1.9023, 95% CI: 1.61-2.23, P_value <0.001), risk score can be used as biomarkers for constructing prognosis. we found significantly higher proportion of low-risk group diagnosed in stage I (82% vs 18%, P_value = 0.035), This model can distinguish in diagnosed stage I CRLM patients with poor prognosis, the model also has a good prognostic effect in validating data and clinical staging. Conclusions: We found that the survival OS of the model risk-high cohort was significant, and is helpful for subsequent treatment.The model risk score was established to be superior to common biomarkers for CRLM, and the discovery of the model is helpful for find metastatic progression the treatment of patients with CRLM. Citation Format: Chunhui Cui, Xintong Wang. The prognostic model of colorectal liver metastases contribute extended molecular profiling [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5878.