En-510-03 sinoatrial node dysfunction in heart failure with preserved ejection fraction

Under normal conditions, the human heart beats over 2 billion times during an average lifetime due to rhythmic electrical impulses initiated in the sinoatrial node (SAN). In disease conditions, such as heart failure with preserved ejection fraction (HFpEF), failure to maintain and regulate the heart rate due to SAN dysfunction can occur. We recently identified latent SAN dysfunction in animal models of cardiometabolic HFpEF. However, little is known about the metabolic imbalances underlying SAN dysfunction in HFpEF.